Fee H J, Kearney J P, Ament M E, Fonkalsrud E W
J Pediatr Surg. 1975 Dec;10(6):959-63. doi: 10.1016/s0022-3468(75)80103-5.
The clinical and histologic changes occurring with antibiotic-associated pseudomembranous colitis are usually reversible with discontinuation of the causative medication. The spectrum of disease patterns ranges from a benign form to a very fulminant and occasionally fatal one. This report describes a child with a severe form of the disease. Despite recognition and sigmoidoscopic confirmation of this syndrome and cessation of antibiotics, his course continued to deteriorate. Sepsis, leukocytosis, refractory diarrhea, and abdominal distension led to exploratory laparotomy. A proctocolectomy was performed for necrosis of the entire colon; however, the patient died of sepsis.
抗生素相关性假膜性结肠炎所出现的临床和组织学变化，通常在停用致病药物后是可逆的。疾病模式的范围从良性形式到非常暴发性且偶尔致命的形式。本报告描述了一名患有严重形式该疾病的儿童。尽管识别并通过乙状结肠镜检查证实了该综合征且停用了抗生素，但他的病情仍继续恶化。败血症、白细胞增多、难治性腹泻和腹胀导致了剖腹探查术。因整个结肠坏死进行了直肠结肠切除术；然而，患者死于败血症。
