Fenton S, Stephenson D, Weder C
Can Med Assoc J. 1974 Nov 16;111(10):1110-1, 1114.
Two cases of pseudomembranous colitis are presented. The first patient had been treated with novobiocin-tetracycline and penicillin, and two weeks later developed severe fulminating diarrhea with ascites and bilateral pleural effusions which did not respond to intravenous ACTH. Subsequently she underwent subtotal colectomy and made a rapid and complete recovery. The second patient developed severe diarrhea two weeks after a 10-day course of clindamycin. She was treated with intravenous ACTH, oral Lactobacillus and a fecal enema and made a complete recovery.These cases reconfirm the importance of antibiotics as etiologic agents in this disease. They also stress the classic sigmoidoscopic and histologic findings that should facilitate prompt and rapid diagnosis.
本文报告两例伪膜性结肠炎。首例患者曾接受新生霉素 - 四环素及青霉素治疗，两周后出现严重暴发性腹泻，伴有腹水及双侧胸腔积液，静脉注射促肾上腺皮质激素（ACTH）治疗无效。随后她接受了次全结肠切除术，并迅速完全康复。第二例患者在接受10天克林霉素治疗后两周出现严重腹泻。她接受了静脉注射ACTH、口服乳酸杆菌及粪便灌肠治疗，最终完全康复。这些病例再次证实了抗生素作为本病病因的重要性。它们还强调了典型的乙状结肠镜检查及组织学表现，这些表现有助于迅速做出诊断。
