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[丘脑神经抑制在创伤后震颤治疗中的应用]

[Thalamic neuro inhibition in the treatment of post traumatic tremor].

作者信息

Martínez-Mañas R, Rumià J, Valldeoriola F, Ferrer E, Tolosa E

机构信息

Servicio de NeurocirugInstitut Clínic de Malalties del SN, Barcelona, 08036, España.

出版信息

Rev Neurol. 2002;34(3):258-61.

Abstract

INTRODUCTION

Severe head trauma could be followed by a wide range of movement disorders. Usually, they appear as a moderate or severe intention tremor that causes great patient disability. Those movement disorders use to be refractary to medical treatment, although sometimes they would be spontaneusly controlled by a year.

CLINICAL CASE

14 year old boy who suffered severe head trauma at age of 8. One year after the injury he developed an action tremor and choreiform dyskinesia with hemibalistic features evocated by the movement. Medical treatment was ineffective. Due to the great patients disability, we chose the surgical treatment based on the placement of an stimulation electrode in thalamic Vop/Vim complex, obtaining a tremor abolition with an improvement in the scales of tremor and quality of life.

DISCUSSION

Surgical treatment of postraumatic tremors tryes to improve in terms of function and activities of daily living, more than suppresion of a symptom. The aim of this treatment is cut the palidal thalamic cortical pathways. Anyway, target is defined by the tremor related cells and, it is more a functional target than an anatomical one. We prefer stimulation more than lesion, due to the lack of brain definitive injury because its reversibility and adjustability features.

摘要

引言

严重头部创伤后可能会出现多种运动障碍。通常,它们表现为中度或重度意向性震颤,给患者带来极大的残疾。这些运动障碍通常对药物治疗无效,尽管有时它们会在一年内自行得到控制。

临床病例

一名14岁男孩,8岁时遭受严重头部创伤。受伤一年后,他出现了动作性震颤和舞蹈样运动障碍,运动时伴有偏身投掷症特征。药物治疗无效。由于患者残疾严重,我们选择了在丘脑腹嘴/腹中间复合体植入刺激电极的手术治疗,震颤消失,震颤量表评分和生活质量得到改善。

讨论

创伤后震颤的手术治疗旨在改善功能和日常生活活动能力,而非仅仅抑制症状。这种治疗的目的是切断苍白球丘脑皮质通路。无论如何,靶点是由与震颤相关的细胞定义的,它更多的是一个功能靶点而非解剖靶点。由于刺激具有可逆性和可调节性,不会造成脑部永久性损伤,所以我们更倾向于刺激而非毁损。

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