Nelson Kristine A, Walsh Declan, Hussein Mohamad
Taussig Cancer Center, Cleveland Clinic Foundation, Ohio, USA.
Am J Hosp Palliat Care. 2002 May-Jun;19(3):206-10. doi: 10.1177/104990910201900313.
Anorexia is a common problem in advanced cancer. Low-dose megestrol acetate, a semi-synthetic progesterone, given twice daily, is an effective appetite stimulant in advanced cancer patients. There was an excellent correlation between patient satisfaction and the primary response criteria (appetite improvement). Given cost, side-effect profile, ease of administration, and efficacy, 80 mg twice daily after meals is an appropriate starting dose of megestrol acetate for anorexia in advanced cancer. If this is not effective, considerable dose escalation is possible.
厌食是晚期癌症患者的常见问题。低剂量醋酸甲地孕酮是一种半合成孕激素，每日服用两次，是晚期癌症患者有效的食欲刺激剂。患者满意度与主要反应标准（食欲改善）之间存在良好的相关性。考虑到成本、副作用、给药便利性和疗效，醋酸甲地孕酮治疗晚期癌症厌食的合适起始剂量为每日两次，每次80mg，餐后服用。如果这一剂量无效，则可以大幅增加剂量。
