Min Daeun, Kim Bonglee, Ko Seong-Gyu, Kim Woojin
Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02453, Korea.
Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul 022447, Korea.
Pharmaceuticals (Basel). 2022 Feb 9;15(2):208. doi: 10.3390/ph15020208.
Cisplatin is a well-known chemotherapeutic agent used to treat various types of cancers; however, it can also induce anorexia, which results in reduced food intake, loss of body weight, and lower quality of life. Although drugs such as megestrol acetate and cyproheptadine are used to decrease this severe feeding disorder, they can also induce side effects, such as diarrhea and somnolence, which limit their widespread use. Various types of herbal medicines have long been used to prevent and treat numerous gastrointestinal tract diseases; however, to date, no study has been conducted to analyze and summarize their effects on cisplatin-induced anorexia. In this paper, we analyze 12 animal studies that used either a single herbal medicine extract or mixtures thereof to decrease cisplatin-induced anorexia. Among the herbal medicines, Ginseng Radix was the most used, as it was included in seven studies, whereas both Glycyrrhizae Radix et Rhizoma and Angelicae Gigantis Radix were used in four studies. As for the mechanisms of action, the roles of serotonin and its receptors, cytokines, white blood cells, ghrelin, and leptin were investigated. Based on these results, we suggest that herbal medicines could be considered a useful treatment method for cisplatin-induced anorexia.
顺铂是一种用于治疗多种癌症的知名化疗药物；然而，它也会诱发厌食症，导致食物摄入量减少、体重减轻和生活质量下降。尽管诸如醋酸甲地孕酮和赛庚啶等药物被用于减轻这种严重的进食障碍，但它们也会引发副作用，如腹泻和嗜睡，这限制了它们的广泛使用。各种草药长期以来一直被用于预防和治疗多种胃肠道疾病；然而，迄今为止，尚未有研究对它们对顺铂诱发的厌食症的影响进行分析和总结。在本文中，我们分析了12项动物研究，这些研究使用单一草药提取物或其混合物来减轻顺铂诱发的厌食症。在这些草药中，人参根使用最为频繁，有7项研究使用了它，而甘草根及根茎和当归根均在4项研究中被使用。至于作用机制，研究了血清素及其受体、细胞因子、白细胞、胃饥饿素和瘦素的作用。基于这些结果，我们认为草药可被视为治疗顺铂诱发的厌食症的一种有用方法。
