泽兰中新型贝壳杉烷型二萜类化合物。

New labdene iterpenes from Eupatorium glutinosum.

作者信息

El-Seedi Hesham R, Sata Noriko, Torssell Kurt B G, Nishiyama Shigeru

机构信息

Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.

出版信息

J Nat Prod. 2002 May;65(5):728-9. doi: 10.1021/np010595r.

DOI:10.1021/np010595r

PMID:12027751

Abstract

The new diterpene glucoside 3,15-dihydroxy-ent-labd-7-en-17-oic acid 3-O-beta-D-glucoside (1) and its aglycone (2) have been isolated from Eupatorium glutinosum. The structures were determined by IR, one- and two-dimensional NMR, high-resolution mass spectrometry, chemical transformations, and comparison of spectroscopic data with closely related diterpenes. Crude extracts showed antimicrobial and cytotoxic activities, but compounds 1 and 2 showed only antimicrobial activity. These results support the vernacular medicinal use of the plant as an antimicrobial.

摘要

从泽兰中分离得到了新的二萜糖苷3,15 - 二羟基 - 对映 - 贝壳杉 - 7 - 烯 - 17 - 酸3 - O - β - D - 葡萄糖苷（1）及其苷元（2）。通过红外光谱、一维和二维核磁共振、高分辨质谱、化学转化以及与密切相关二萜的光谱数据比较确定了其结构。粗提物显示出抗菌和细胞毒性活性，但化合物1和2仅显示出抗菌活性。这些结果支持了该植物作为抗菌剂的民间药用。