从巴西特有的海洋海绵Caissara Aplysina中分离出两种前所未有的二溴酪氨酸衍生生物碱。

Two unprecedented dibromotyrosine-derived alkaloids from the Brazilian endemic marine sponge Aplysina caissara.

作者信息

Saeki Beatriz M, Granato Ana Claudia, Berlinck Roberto G S, Magalhães Alviclér, Schefer Alexandre B, Ferreira Antonio G, Pinheiro Ulisses S, Hajdu Eduardo

机构信息

Instituto de Química de São Carlos, Universidade de São Paulo CP 780, CEP 13560-970, São Carlos, SP, Brazil.

出版信息

J Nat Prod. 2002 May;65(5):796-9. doi: 10.1021/np0105735.

DOI:10.1021/np0105735

PMID:12027773

Abstract

Two new bromotyrosine-derived alkaloids, caissarine A (1) and caissarine B (2), along with three known biogenetically related alkaloids, aeroplysinin-1, fistularin-3, and the artifact of isolation 2-(3,5-dibromo-4-dimethoxy-1-hydroxy-2,5-cyclohexadien-1-yl)ethanamide, have been isolated from Aplysina caissara, an endemic species of marine sponge from the Southeastern Brazilian coast. The alkaloids have been identified by analysis of spectroscopic data. While caissarine A has a 2-hydroxyagmatine moiety in its structure, caissarin B is the first naturally occurring compound encompassing the unprecedented 1,7-diamino-3-hydroxyheptane moiety.

摘要

从巴西东南海岸特有的海洋海绵Caissara中分离出两种新的溴酪氨酸衍生生物碱，caissarine A（1）和caissarine B（2），以及三种已知的生物源相关生物碱，aeroplysinin-1、fistularin-3和分离产物2-(3,5-二溴-4-二甲氧基-1-羟基-2,5-环己二烯-1-基)乙酰胺。通过光谱数据分析鉴定了这些生物碱。虽然caissarine A在其结构中具有2-羟基胍丁胺部分，但caissarin B是第一个天然存在的包含前所未有的1,7-二氨基-3-羟基庚烷部分的化合物。