酪氨酸拉定碱C-F，来自Verongid海绵的新型溴酪氨酸生物碱。

Tyrokeradines C-F, new bromotyrosine alkaloids from the Verongid sponges.

作者信息

Kubota Takaaki, Watase Shinya, Mukai Hiroya, Fromont Jane, Kobayashi Jun'ichi

机构信息

Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060–0812, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2012;60(12):1599-601. doi: 10.1248/cpb.c12-00785.

DOI:10.1248/cpb.c12-00785

PMID:23207640

Abstract

Four new bromotyrosine alkaloids, tyrokeradines C-F (1-4), have been isolated from Okinawan marine sponges of the order Verongidae. The structures of 1-4 were elucidated on the basis of spectroscopic data. Tyrokeradines C (1) and D (2) are new bromotyrosine alkaloids possesing an imidazole ring, while tyrokeradines E (3) and F (4) are new bromotyrosine alkaloids possesing a cyano group.

摘要

从属于Verongidae目的冲绳海洋海绵中分离出了四种新的溴酪氨酸生物碱，即tyrokeradines C-F（1-4）。根据光谱数据阐明了1-4的结构。Tyrokeradines C（1）和D（2）是具有咪唑环的新溴酪氨酸生物碱，而tyrokeradines E（3）和F（4）是具有氰基的新溴酪氨酸生物碱。