Porrata Luis F, Inwards David J, Micallef Ivana N, Ansell Stephen M, Geyer Susan M, Markovic Svetomir N
Division of Hematology and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Br J Haematol. 2002 Jun;117(3):629-33. doi: 10.1046/j.1365-2141.2002.03478.x.
A retrospective study of 82 patients was conducted to determine the relationship of absolute lymphocyte count (ALC) recovery with clinical outcome after autologous stem cell transplantation (ASCT) in Hodgkin's disease (HD). The median overall (OS) and progression-free survival (PFS) times from the day of transplantation were significantly better for the 41 patients with ALC > or = 0.5 x 10(9) cells/l compared with the 41 patients with ALC < 0.5 x 10(9) cells/l ("not yet reached" versus 42 months, P < 0.0001; 57 versus 15 months, P < 0.002 respectively). Thus, ALC recovery on day 15 post ASCT in HD is associated with better survival and requires further study.
对82例患者进行了一项回顾性研究，以确定霍奇金淋巴瘤（HD）患者自体干细胞移植（ASCT）后绝对淋巴细胞计数（ALC）恢复与临床结局之间的关系。与41例ALC<0.5×10⁹细胞/升的患者相比，41例ALC≥0.5×10⁹细胞/升的患者从移植日起的中位总生存期（OS）和无进展生存期（PFS）明显更好（“未达到”对42个月，P<0.0001；57对15个月，P<0.002）。因此，HD患者ASCT后第15天的ALC恢复与更好的生存率相关，需要进一步研究。
