Pastor Maria Antonia, Carrasco Loreto, Izquierdo Maria José, Fariña Maria Carmen, Martín Lucia, Renedo Guadalupe, Requena Luis
Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
J Cutan Pathol. 2002 Apr;29(4):193-9. doi: 10.1034/j.1600-0560.2002.290401.x.
Chloracne is an acneiform eruption due to poisoning by halogenated aromatic compounds having a specific molecular shape. This condition is always a symptom of systemic poisoning by chemical chloracnegens and not just a cutaneous disorder.
We have studied a patient with severe chloracne who showed cutaneous lesions involving mostly the face and the axillae.
Histopathologic study of the facial lesions demonstrated that almost every vellus hair follicle was involved, showing a dilated infundibulum filled by a keratotic plug. This keratotic material was mostly composed of orthokeratotic basket-weave basophilic corneocytes, namely infundibular keratin, although there were also some dilated infundibula containing eosinophilic laminated or granular sebum at their center. Small infundibular cysts were more numerous than comedones. Mature and well-developed sebaceous glands were seen at the base of many of the dilated infundibula and no squamous metaplasia of the sebaceous glands or ducts could be demonstrated. Hyperpigmentation of the lesions resulted from hyperproduction of melanin by a normal number of melanocytes along the basal layer of the epidermis and infundibular epithelium. Abundant melanin granules also impregnated the corneocytes of the infundibular plugs.
Our findings support the notion that tiny infundibular cysts rather than comedones represent the basic lesions of chloracne.
氯痤疮是一种由具有特定分子形状的卤代芳香族化合物中毒引起的痤疮样皮疹。这种情况始终是化学性氯痤疮原全身中毒的症状，而不仅仅是一种皮肤疾病。
我们研究了一名患有严重氯痤疮的患者，其皮肤损害主要累及面部和腋窝。
对面部损害的组织病理学研究表明，几乎每个毳毛毛囊都受累，显示漏斗部扩张，充满角质栓。这种角质物质主要由正角化的篮状嗜碱性角质形成细胞组成，即漏斗部角质，尽管也有一些扩张的漏斗部中央含有嗜酸性层状或颗粒状皮脂。小漏斗部囊肿比粉刺更常见。在许多扩张的漏斗部底部可见成熟且发育良好的皮脂腺，未发现皮脂腺或导管的鳞状化生。病变处色素沉着是由于沿表皮基底层和漏斗部上皮的正常数量黑素细胞产生过多黑色素所致。丰富的黑色素颗粒也浸染了漏斗部角质栓的角质形成细胞。
我们的研究结果支持这样一种观点，即微小的漏斗部囊肿而非粉刺是氯痤疮的基本损害。
