芳香烃受体/芳香烃受体核转运蛋白系统在皮肤稳态中的作用。
Role of AhR/ARNT system in skin homeostasis.
作者信息
Furue Masutaka, Takahara Masakazu, Nakahara Takeshi, Uchi Hiroshi
机构信息
Department of Dermatology, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka, 812-8582, Japan,
出版信息
Arch Dermatol Res. 2014 Nov;306(9):769-79. doi: 10.1007/s00403-014-1481-7. Epub 2014 Jun 26.
Abstract
Aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that binds to structurally diverse synthetic and naturally occurring chemicals including dioxins, flavonoids, tryptophan photoproducts, and Malassezia metabolites. Upon binding to its ligands, cytoplasmic AhR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT), and mediates numerous biological and toxicological effects by inducing the transcription of various AhR-responsive genes. AhR ligation controls oxidation/antioxidation, epidermal barrier function, photo-induced response, melanogenesis, and innate immunity. This review summarizes recent advances in the understanding of the regulatory mechanisms of skin homeostasis mediated by the AhR/ARNT system.
摘要
芳烃受体（AhR）是一种依赖配体的转录因子，可与结构多样的合成及天然化学物质结合，包括二恶英、类黄酮、色氨酸光产物和马拉色菌代谢产物。与配体结合后，细胞质中的AhR转位至细胞核，与芳烃受体核转运蛋白（ARNT）形成异二聚体，并通过诱导各种AhR反应基因的转录介导多种生物学和毒理学效应。AhR配体结合可调控氧化/抗氧化、表皮屏障功能、光诱导反应、黑色素生成和先天免疫。本综述总结了对AhR/ARNT系统介导的皮肤稳态调节机制的最新认识进展。
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