一种来自多花阿兰木犀榄的异戊烯基黄酮。

A prenylated xanthone from Allanblackia floribunda.

作者信息

Nkengfack Augustin E, Azebaze Guy A, Vardamides Juliette C, Fomum Zacharias T, van Heerden Fanie R

机构信息

Department of Organic Chemistry, Faculty of Science, University of Yaounde I, PO Box 812, Yaounde, Cameroon.

出版信息

Phytochemistry. 2002 Jun;60(4):381-4. doi: 10.1016/s0031-9422(02)00036-5.

DOI:10.1016/s0031-9422(02)00036-5

PMID:12031429

Abstract

A new prenylated xanthone, named allanxanthone A, was isolated from the stem bark of Allanblackia floribunda in addition to known compounds, 1,5-dihydoxyxanthone, 1,5,6-trihydroxy-3,7-dimethoxyxanthone, stigmasterol and stigmasteryl-3-O-beta-D-glucopyranoside. The structure of the new compound was assigned as 1,3,5-trihydroxy-2-(3-methylbut-2-enyl)-4-(1,1-dimethylprop-2-enyl) xanthone, by means of spectroscopic analysis. The 13C NMR spectral data of 1,5-dihydroxyxanthone is reported here for the first time as well as the in vitro cytotoxic activity of xanthone metabolites against the KB cell line.

摘要

除了已知化合物1,5 - 二羟基呫吨酮、1,5,6 - 三羟基 - 3,7 - 二甲氧基呫吨酮、豆甾醇和豆甾醇 - 3 - O - β - D - 吡喃葡萄糖苷外，从多花阿林藤的茎皮中分离出一种新的异戊烯基呫吨酮，命名为阿林呫吨酮A。通过光谱分析，将新化合物的结构确定为1,3,5 - 三羟基 - 2 - (3 - 甲基丁 - 2 - 烯基) - 4 - (1,1 - 二甲基丙 - 2 - 烯基)呫吨酮。本文首次报道了1,5 - 二羟基呫吨酮的13C NMR光谱数据以及呫吨酮代谢物对KB细胞系的体外细胞毒性活性。