Magnusson Jane E, Martin Roxanne V
Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, 1403 29th Street NW, Calgary, Alberta, Canada T2N 2T9.
Brain Res. 2002 Jun 28;942(1-2):128-32. doi: 10.1016/s0006-8993(02)02489-7.
Identification of the brain areas that contribute to pain is an essential undertaking towards understanding persistent pain. Areas of the basal ganglia have been proposed to play important roles in nociception as previous studies have determined the involvement of the substantia nigra pars compacta and the dorsolateral striatum in pain. The purpose of the present study was therefore to expand upon these findings by determining the involvement of other areas of the basal ganglia such as the nucleus accumbens shell and core in formalin-induced nociception. It was found that injection of a local anaesthetic (bupivacaine) into the nucleus accumbens shell had no effect on formalin-induced nociception. However, injection into the nucleus accumbens core enhanced formalin-induced nociception. These results implicate the nucleus accumbens in the processing of pain and provide additional evidence for the involvement of the basal ganglia and possibly dopamine in pain.
确定对疼痛有影响的脑区是理解持续性疼痛的一项重要工作。由于先前的研究已确定黑质致密部和背外侧纹状体参与疼痛过程，因此有人提出基底神经节区域在伤害感受中起重要作用。因此，本研究的目的是通过确定基底神经节的其他区域（如伏隔核壳和核心）在福尔马林诱导的伤害感受中的参与情况来扩展这些发现。研究发现，向伏隔核壳注射局部麻醉剂（布比卡因）对福尔马林诱导的伤害感受没有影响。然而，向伏隔核核心注射则增强了福尔马林诱导的伤害感受。这些结果表明伏隔核参与了疼痛处理，并为基底神经节以及可能的多巴胺参与疼痛提供了额外证据。
