99mTc-N,N'-双（氨乙基）丙二胺六乙酸（BPHA）：一种类似于99mTc-二乙三胺五乙酸（DTPA）的肾小球滤过剂。

99mTc-N, N'-bis(aminoethyl)propanediamine hexaacetic acid (BPHA): a glomerular filtration agent similar to 99mTc-DTPA.

作者信息

Liu Guozheng, Zhang Chunli, Liu Fei, Wang Rongfu, Fu Zhanli, Li Guiqun, Miao Zengxing

机构信息

Isotope Department, China Institute of Atomic Energy, Beijing, Peoples Republic of China.

出版信息

Nucl Med Biol. 2002 May;29(4):399-404. doi: 10.1016/s0969-8051(02)00302-5.

DOI:10.1016/s0969-8051(02)00302-5

PMID:12031874

Abstract

Investigations on the biodistribution of 99mTc-BPHA in normal and probenecid treated mice and a comparison with 99mTc-DTPA injected mice suggested that 99mTc-BPHA is also a glomerular filtration agent. Whole body radioactivity measurements in mice and rabbits after administration of 99mTc-BPHA showed negligible whole body radioactivity at 24 h. Excellent kidney images both in rabbits and a human volunteer were obtained. The significance of higher GFR estimates using 99mTc-BPHA compared to 99mTc-DTPA is discussed.

摘要

对99mTc-BPHA在正常小鼠和丙磺舒处理小鼠体内生物分布的研究，以及与注射99mTc-DTPA小鼠的比较表明，99mTc-BPHA也是一种肾小球滤过剂。给予99mTc-BPHA后，对小鼠和兔子进行的全身放射性测量显示，24小时时全身放射性可忽略不计。在兔子和一名人类志愿者身上均获得了出色的肾脏图像。讨论了与99mTc-DTPA相比，使用99mTc-BPHA估算肾小球滤过率（GFR）更高的意义。