99mTc（铜）-甘露醇复合物：一种用于动态肾功能研究的新型试剂。

99mTc(Cu)-mannitol complex: a new agent for dynamic renal function studies.

作者信息

Chauhan U P, Chander J, Mishra P, Sarin R C, Narayanan R V, Singh B

机构信息

Institute of Nuclear Medicine and Allied Sciences, Delhi-, India.

出版信息

Int J Rad Appl Instrum B. 1989;16(3):283-9. doi: 10.1016/0883-2897(89)90009-3.

DOI:10.1016/0883-2897(89)90009-3

PMID:2497090

Abstract

Mannitol has been labeled with 99mTc by using cuprous chloride as a reducing agent. Blood and kidney clearance of 99mTc(Cu)-mannitol was slightly faster than that of 99mTc(Sn)-DPTA in rat and maximum radioactivity ratio of kidneys to blood was 84.6 at 5 min. A comparative study of 99mTc(Cu)-mannitol, 99mTc(Sn)-DTPA was made in rabbits by taking serial images of kidneys and bladder with a gamma camera. Results show superiority of 99mTc(Cu)-mannitol over other agents for dynamic renal function studies.

摘要

通过使用氯化亚铜作为还原剂，已用99mTc标记了甘露醇。在大鼠体内，99mTc（铜）-甘露醇的血液和肾脏清除率略快于99mTc（锡）-二乙三胺五乙酸（DTPA），并且在5分钟时肾脏与血液的最大放射性比值为84.6。通过使用γ相机对兔子的肾脏和膀胱进行连续成像，对99mTc（铜）-甘露醇和99mTc（锡）-DTPA进行了比较研究。结果表明，99mTc（铜）-甘露醇在动态肾功能研究方面优于其他试剂。