血管紧张素转换酶（ACE）基因的插入/缺失多态性与2型糖尿病相关。
Insertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes.
作者信息
Feng Yan, Niu Tianhua, Xu Xin, Chen Changzhong, Li Qiongfang, Qian Rongli, Wang Guoying, Xu Xiping
机构信息
Division of Endocrinology, the Third Affiliated Hospital of Beijing University, Beijing, China.
出版信息
Diabetes. 2002 Jun;51(6):1986-8. doi: 10.2337/diabetes.51.6.1986.
In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, and 10.4% in the control group. The DD frequency was significantly higher in the case group than in the control group (chi(2)(1) = 4.77, P = 0.03), suggesting that the DD genotype is associated with an increased susceptibility to type 2 diabetes in our study population.
为了研究血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性在2型糖尿病中的作用，我们在中国北方的132对夫妇中进行了一项病例对照关联研究。病例组中II、ID和DD基因型频率分别为39.8%、39.8%和20.3%，对照组中分别为44.8%、44.8%和10.4%。病例组中DD频率显著高于对照组（χ²(1)=4.77，P = 0.03），表明在我们的研究人群中，DD基因型与2型糖尿病易感性增加有关。
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