Memiş Dilek, Turan Alparslan, Karamanlioğlu Beyhan, Süt Necdet, Pamukçu Zafer
Department of Anaesthesiology, Medical Facility, Trakya University, 22030 Edirne, Turkey.
Anesth Analg. 2002 Jun;94(6):1517-20, table of contents. doi: 10.1097/00000539-200206000-00026.
We compared the efficacy of ondansetron, lidocaine, tramadol, and fentanyl in minimizing pain caused by the injection of rocuronium in 250 patients. After tourniquet application on the forearm, the patients were given saline (3 mL) (Group 1, n = 50), ondansetron (4 mg) (Group 2, n = 50), lidocaine (30 mg) (Group 3, n = 50), tramadol (50 mg) (Group 4, n = 50), or fentanyl (100 microg) (Group 5, n = 50) diluted into a 3-mL solution. The occlusion was released after 20 s and rocuronium was injected over 10-15 s. The patients were observed and asked immediately if they had pain in the arm, and the response was assessed. Reactions such as discomfort and pain, withdrawal of the hand, and so on after the administration of rocuronium were recorded as side effects for 24 h. Ten patients in Group 1, 28 patients in Group 2, 37 patients in Group 3, 30 patients in Group 4, and 15 patients in Group 5 reported no pain. Light pain was seen in 11 patients in Group 1, 14 patients in Group 2, 11 patients in Group 3, 12 patients in Group 4, and 20 patients in Group 5. Moderate pain was seen in 15 patients in Group 1, 6 patients in Group 2, 2 patients in Group 3, 8 patients in Group 4, and 10 patients in Group 5. Severe pain was seen in 14 patients in Group 1, 2 patients in Group 2, 0 patients in Group 3, 0 patients in Group 4, and 5 patients in Group 5. Correlation determined with log-linear analysis found in Group 1 pain score 0 (P < 0.001), Group 1 pain score 1 (P < 0.001), and Group 3 pain score 0 (P < 0.001). We conclude that ondansetron, lidocaine, tramadol, and fentanyl decrease the level of rocuronium injection pain. Among these drugs, lidocaine is the most effective, whereas fentanyl is the least effective.
We compared the efficacy of ondansetron, lidocaine, tramadol, and fentanyl in minimizing the pain on injection of rocuronium in 250 patients. Ondansetron, lidocaine, tramadol, and fentanyl were effective in preventing and decreasing the level of rocuronium injection pain. Among these drugs, lidocaine was the most effective, and fentanyl was the least effective.
我们比较了昂丹司琼、利多卡因、曲马多和芬太尼在250例患者中减轻罗库溴铵注射所致疼痛的效果。在前臂应用止血带后，给患者分别注射生理盐水（3毫升）（第1组，n = 50）、昂丹司琼（4毫克）（第2组，n = 50）、利多卡因（30毫克）（第3组，n = 50）、曲马多（50毫克）（第4组，n = 50）或芬太尼（100微克）（第5组，n = 50），均稀释至3毫升溶液中。20秒后松开止血带，并在10 - 15秒内注射罗库溴铵。观察患者并立即询问其手臂是否疼痛，并评估反应。罗库溴铵给药后出现的不适、疼痛、手部回缩等反应记录为24小时内的副作用。第1组10例患者、第2组28例患者、第3组37例患者、第4组30例患者和第5组15例患者报告无疼痛。第1组11例患者、第2组14例患者、第3组11例患者、第4组12例患者和第5组20例患者出现轻度疼痛。第1组15例患者、第2组6例患者、第3组2例患者、第4组8例患者和第5组10例患者出现中度疼痛。第1组14例患者、第2组2例患者、第3组0例患者、第4组0例患者和第5组5例患者出现重度疼痛。通过对数线性分析确定的相关性显示，第1组疼痛评分0（P < 0.001）、第1组疼痛评分1（P < 0.001）和第3组疼痛评分0（P < 0.001）。我们得出结论，昂丹司琼、利多卡因、曲马多和芬太尼可降低罗库溴铵注射疼痛程度。在这些药物中，利多卡因最有效，而芬太尼最无效。
我们比较了昂丹司琼、利多卡因、曲马多和芬太尼在250例患者中减轻罗库溴铵注射疼痛的效果。昂丹司琼、利多卡因、曲马多和芬太尼在预防和降低罗库溴铵注射疼痛程度方面有效。在这些药物中，利多卡因最有效，芬太尼最无效。
