Turan A, Memis D, Karamanlioglu B, Sut N, Pamukcu Z
Departments of Anaesthesiology and Biostatistics, Medical Faculty, Trakya University, Edirne, Turkey.
Anaesth Intensive Care. 2003 Jun;31(3):277-81. doi: 10.1177/0310057X0303100306.
We compared the efficacy of magnesium sulphate, lignocaine, sodium bicarbonate or alfentanil in minimizing pain due to injection of rocuronium in 250 patients. After tourniquet application on the forearm, the patients were given saline, magnesium sulphate, lignocaine, sodium bicarbonate 8.4% or alfentanil, diluted into a 3 ml solution. The occlusion was released after 20 seconds, and rocuronium was injected over 10 to 15 seconds. The patients were observed and asked immediately if they had pain in the arm and the response was assessed. Reactions such as discomfort and pain, withdrawal of the hand and screaming after the administering of the rocuronium were recorded as side-effects and patients were reassessed at 24 hours postoperatively. We concluded that magnesium sulphate, lignocaine, sodium bicarbonate or alfentanil decreased the level of rocuronium injection pain. Of these drugs, magnesium sulphate, lignocaine and sodium bicarbonate were the most effective while alfentanil was the least effective.
我们比较了硫酸镁、利多卡因、碳酸氢钠或阿芬太尼在250例患者中减轻罗库溴铵注射所致疼痛的疗效。在前臂应用止血带后，给患者输注生理盐水、硫酸镁、利多卡因、8.4%碳酸氢钠或阿芬太尼，稀释成3ml溶液。20秒后松开止血带，在10至15秒内注射罗库溴铵。观察患者并立即询问其手臂是否疼痛，并评估反应。将注射罗库溴铵后出现的不适、疼痛、缩手及尖叫等反应记录为副作用，并在术后24小时对患者进行重新评估。我们得出结论，硫酸镁、利多卡因、碳酸氢钠或阿芬太尼可降低罗库溴铵注射疼痛程度。在这些药物中，硫酸镁、利多卡因和碳酸氢钠最有效，而阿芬太尼最无效。
