Zambrano-Villa Sergio, Rosales-Borjas Disney, Carrero Julio César, Ortiz-Ortiz Librado
Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Trends Parasitol. 2002 Jun;18(6):272-8. doi: 10.1016/s1471-4922(02)02289-4.
Protozoan pathogens such as Plasmodium, Leishmania, Trypanosoma and Entamoeba are responsible for several of the most widespread and lethal human diseases. Their successful survival depends mainly on evading the host immune system by, for example, penetrating and multiplying within cells, varying their surface antigens, eliminating their protein coat, and modulating the host immune response. Immunosuppression is sometimes caused directly by parasite products and sometimes involves antigenic mimicry, which often appears in association with parasitic diseases. However, one of the most sophisticated mechanisms of evasion is the selective activation of a subset of T helper cells.
疟原虫、利什曼原虫、锥虫和内阿米巴等原生动物病原体是几种最广泛传播且致命的人类疾病的病原体。它们的成功存活主要依赖于逃避宿主免疫系统，例如，在细胞内穿透和繁殖、改变其表面抗原、去除其蛋白外壳以及调节宿主免疫反应。免疫抑制有时直接由寄生虫产物引起，有时涉及抗原模拟，这常与寄生虫病相关联。然而，最复杂的逃避机制之一是选择性激活一部分辅助性T细胞。
