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揭示致病病原体的多样性:对原生动物、真菌和蠕虫感染的见解。

Uncovering the diversity of pathogenic invaders: insights into protozoa, fungi, and worm infections.

作者信息

Shukla Richa, Soni Jyoti, Kumar Ashish, Pandey Rajesh

机构信息

Division of Immunology and Infectious Disease Biology, INGEN-HOPE (INtegrative GENomics of HOst-PathogEn) Laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India.

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.

出版信息

Front Microbiol. 2024 Mar 25;15:1374438. doi: 10.3389/fmicb.2024.1374438. eCollection 2024.

DOI:10.3389/fmicb.2024.1374438
PMID:38596382
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11003270/
Abstract

Post COVID-19, there has been renewed interest in understanding the pathogens challenging the human health and evaluate our preparedness towards dealing with health challenges in future. In this endeavour, it is not only the bacteria and the viruses, but a greater community of pathogens. Such pathogenic microorganisms, include protozoa, fungi and worms, which establish a distinct variety of disease-causing agents with the capability to impact the host's well-being as well as the equity of ecosystem. This review summarises the peculiar characteristics and pathogenic mechanisms utilized by these disease-causing organisms. It features their role in causing infection in the concerned host and emphasizes the need for further research. Understanding the layers of pathogenesis encompassing the concerned infectious microbes will help expand targeted inferences with relation to the cause of the infection. This would strengthen and augment benefit to the host's health along with the maintenance of ecosystem network, exhibiting host-pathogen interaction cycle. This would be key to discover the layers underlying differential disease severities in response to similar/same pathogen infection.

摘要

新冠疫情之后,人们重新燃起了对了解挑战人类健康的病原体以及评估我们应对未来健康挑战的准备情况的兴趣。在这一努力过程中,不仅有细菌和病毒,还有更广泛的病原体群体。这类致病微生物包括原生动物、真菌和蠕虫,它们构成了种类繁多的致病因子,有能力影响宿主的健康以及生态系统的平衡。本综述总结了这些致病生物所具有的独特特征和致病机制。它阐述了它们在相关宿主中引发感染的作用,并强调了进一步研究的必要性。了解涉及相关感染微生物的发病机制层次,将有助于扩展与感染原因相关的有针对性的推断。这将加强并增加对宿主健康的益处,同时维持生态系统网络,展示宿主 - 病原体相互作用循环。这将是发现针对相似/相同病原体感染时不同疾病严重程度背后层次的关键。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a19/11003270/678f48c71457/fmicb-15-1374438-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a19/11003270/9dc1331077de/fmicb-15-1374438-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a19/11003270/d90887bfe594/fmicb-15-1374438-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a19/11003270/a2c40b6c13ed/fmicb-15-1374438-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a19/11003270/678f48c71457/fmicb-15-1374438-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a19/11003270/9dc1331077de/fmicb-15-1374438-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a19/11003270/d90887bfe594/fmicb-15-1374438-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a19/11003270/a2c40b6c13ed/fmicb-15-1374438-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a19/11003270/678f48c71457/fmicb-15-1374438-g004.jpg

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