Worwood Mark
Department of Haematology, University of Wales College of Medicine, Cardiff, UK.
Ann Clin Biochem. 2002 May;39(Pt 3):221-30. doi: 10.1258/0004563021902152.
Most cells acquire iron from plasma transferrin and it is the transferrin receptor that is responsible for the internalization of transferrin-bound iron and its subsequent intracellular release. Plasma concentrations of the receptor reflect cellular receptor numbers and may be determined by enzyme immunoassay on automated analysers. Although determination of receptor concentrations may provide little additional value to existing measures of iron status, particular circumstances may dictate the use of these assays. This review summarizes transferrin receptor physiology and biochemistry, the limitations of the methodology that is currently available and the clinical application of assays (a) in monitoring changes in the rate of erythropoiesis, (b) as an indicator of developing iron deficiency and (c) in identifying iron deficiency in patients with anaemia of chronic disease.
大多数细胞从血浆转铁蛋白中获取铁，而转铁蛋白受体负责结合转铁蛋白的铁的内化及其随后的细胞内释放。受体的血浆浓度反映细胞受体数量，可通过自动分析仪上的酶免疫测定法来确定。尽管受体浓度的测定对现有的铁状态测量方法可能没有太大的附加价值，但在特定情况下可能需要使用这些检测方法。本综述总结了转铁蛋白受体的生理学和生物化学、现有方法的局限性以及检测方法在以下方面的临床应用：(a)监测红细胞生成速率的变化；(b)作为缺铁发展的指标；(c)识别慢性病贫血患者的缺铁情况。
