Anju Joy, Abhishekh Basavarajegowda, Debdatta Basu, Bobby Zachariah, Sharan Murali
Department of Transfusion Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Asian J Transfus Sci. 2022 Jul-Dec;16(2):186-193. doi: 10.4103/ajts.ajts_119_21. Epub 2022 Sep 28.
Regular blood donation depletes iron stores. The assertion is that the vulnerable donor population requires a predictive standard operative procedure for early detection of iron store depletion, preventing them from developing iron-deficiency anemia.
This study aims to study the potential effects of blood donation in the regular donor group using hematological and biochemical estimation of iron status parameters.
This was a prospective cross-sectional study on regular blood donors, defined as those who have donated at least 3 times, the last donation being within the last 12 months and continues to donate at least once a year, at a tertiary care teaching hospital in Southern India.
The complete blood count (CBC) was performed on the Sysmex coulter, and the red cell indices were calculated. The ferritin and the soluble transferrin receptor (sTfR) assays were performed using Enzyme Immunoassays.
The comparison of CBC, serum ferritin, and sTfR assay with donation frequency and time since the last donation was carried out using an independent student's -test for two groups. The statistical analysis was performed using SPSS for Windows version 20.
A total of 323 regular blood donors (6 were females) were included in the study of which they were categorized into three, 211 donors with less than or equal to 10 donations, 84 those who had donated between 11 and 20 times and 28 who had donated more than 20 times. The red cell indices were reduced and different in the groups but not statistically significant except for mean corpuscular volume. About 15% of the study population had a transferrin level of <15 ng/ml. The Ferritin levels showed a statistically significant negative correlation with the number of donations, the correlation coefficient being -0.27. Logarithmic ratios of sTfR/ferritin also correlated with a coefficient of 0.156 with the number of donations and were statistically significant.
Our study found that regular blood donors had low iron stores, as shown by ferritin levels and other iron indicators. Using the current guidelines (hemoglobin >12.5 g/dL) for donation, or the red cell indices alone do not reflect the donor's actual iron status.
定期献血会消耗铁储备。有一种观点认为，易受影响的献血人群需要一种预测性标准操作程序，以便早期检测铁储备耗竭情况，防止他们发展为缺铁性贫血。
本研究旨在通过对铁状态参数进行血液学和生化评估，研究定期献血对定期献血者群体的潜在影响。
这是一项针对定期献血者的前瞻性横断面研究，定期献血者定义为那些至少献血3次、最后一次献血在过去12个月内且继续每年至少献血一次的人，研究地点为印度南部一家三级护理教学医院。
使用Sysmex血细胞分析仪进行全血细胞计数（CBC），并计算红细胞指数。使用酶免疫测定法进行铁蛋白和可溶性转铁蛋白受体（sTfR）检测。
使用独立样本t检验对CBC、血清铁蛋白和sTfR检测结果与献血频率及上次献血后的时间进行两组间比较。使用SPSS for Windows 20版本进行统计分析。
本研究共纳入323名定期献血者（6名女性），他们被分为三组，211名献血次数小于或等于10次的献血者，84名献血11至20次的献血者，以及28名献血超过20次的献血者。红细胞指数在各组中有所降低且存在差异，但除平均红细胞体积外无统计学意义。约15%的研究人群转铁蛋白水平<15 ng/ml。铁蛋白水平与献血次数呈统计学显著负相关，相关系数为-0.27。sTfR/铁蛋白的对数比值与献血次数的相关系数为0.156，且具有统计学意义。
我们的研究发现，从铁蛋白水平和其他铁指标来看，定期献血者的铁储备较低。按照目前的献血指南（血红蛋白>12.5 g/dL）或仅依靠红细胞指数并不能反映献血者的实际铁状态。
