[肺功能随年龄下降的生理方面]
[Physiological aspects of the decline of pulmonary function with age].
作者信息
Guénard H, Rouatbi S
机构信息
Service d'Exploration Fonctionnelle du CHU de Bordeaux et Laboratoire de Physiologie de l'Université Victor Segalen Bordeaux II, Bordeaux.
出版信息
Rev Mal Respir. 2002 Apr;19(2 Pt1):230-40.
After peaking between the age of 20 and 30 years, pulmonary function declines gradually with age. This decline is related to changes in respiratory dynamics (lung mechanics, gas exchange) and also to non-respiratory factors (e.g. changes in the immune system). This age-related fall in pulmonary function is not linear, for example there is no further decline in mean PaO(2) in men and women, nor in the FEV1/FVC ratio in men, after the age of 70 years. Caution is required when interpreting changes in pulmonary mechanics in the elderly due to greater variability of reference values in this age group.
在20至30岁达到峰值后，肺功能会随着年龄的增长而逐渐下降。这种下降与呼吸动力学变化（肺力学、气体交换）以及非呼吸因素（如免疫系统变化）有关。这种与年龄相关的肺功能下降并非呈线性，例如，70岁以后，男性和女性的平均动脉血氧分压（PaO₂）以及男性的第一秒用力呼气容积/用力肺活量（FEV₁/FVC）比值均不再进一步下降。由于该年龄组参考值的变异性较大，在解释老年人肺力学变化时需要谨慎。
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