Hamaguchi Taizo, Nagase Machiko, Higuchi Ryota, Takiuchi Iwao
Department of Dermatology, Showa University, Northern Yokohama Hospital, Japan.
Nihon Ishinkin Gakkai Zasshi. 2002;43(2):95-8. doi: 10.3314/jjmm.43.95.
We described here a case of a 43-year-old male who developed confluent and reticulated papillomatosis (CRP). The patient was found to be slightly obese and had no family history of such eruption. Numerous small red-brown erythemas were scattered over a wide area of the back and, in many areas, the erythemas coalesced and formed a reticular pattern. The eruptions appeared 10 days prior to the initial visit to our outpatient clinic. The Parker-KOH preparation of scraped scales revealed numerous round and budding non-clustering cells and no mycelial elements. Histological examination showed subtle papillomatosis and sparse perivascular lymphohistiocytic infiltrations. Periodic acid schiff stain showed a few spores in the stratum corneum. Topical application of 2% ketoconazole cream produced complete resolution of the eruption in 7 days. The course and histological findings of our patient suggest the eruptions were developing CRP lesions. Application of topical antifungal agents appears to be a beneficial initial treatment for early CRP lesions.
我们在此描述了一例43岁男性患融合性网状乳头瘤病（CRP）的病例。该患者略显肥胖，无此类皮疹的家族史。大量小红褐色红斑散在于背部广泛区域，在许多部位，红斑融合并形成网状图案。皮疹在初次就诊于我们门诊前10天出现。刮取鳞屑的派克-氢氧化钾涂片显示有大量圆形和芽生的非聚集性细胞，未见菌丝成分。组织学检查显示有轻微乳头瘤病和稀疏的血管周围淋巴细胞组织细胞浸润。高碘酸希夫染色显示角质层有少量孢子。局部应用2%酮康唑乳膏7天内皮疹完全消退。我们患者的病程和组织学表现提示皮疹为CRP病变。局部应用抗真菌药物似乎是早期CRP病变有益的初始治疗方法。
