Murakami Maki, Morikawa Akio, Okabe Ryugo, Hayashi Ken, Miyazawa Koichi, Iijima Satoshi, Ozaki Kazunori, Suzuki Akira, Koyama Yoshinori, Sugiyama Atsushi
Dept. of Surgery, Showa Inan General Hospital.
Gan To Kagaku Ryoho. 2002 May;29(5):767-70.
We report three patients with recurrent gastric cancer responding to TS-1 therapy after combination chemotherapy with 5-fluorouracil, mitomycin C and cisplatin. All 3 cases had undergone total gastrectomy with lymphadenectomy for advanced gastric cancer. Postoperative follow-up computed tomography (CT) showed liver metastases (cases 1 and 3), peritoneal dissemination (case 2) and enlargement of paraaortic lymph nodes (case 1) due to cancer recurrence. After 2 to 4 courses of combined treatment with 5-fluorouracil (500-750 mg/body/day, days 1-5, civ), mitomycin C (6-8 mg/body, day 6) and cisplatin (60-80 mg/body, day 7), CT revealed considerable reduction of the metastatic tumors. Subsequently oral administration of TS-1 (80-100 mg/body/day) for 4 weeks was performed. All 3 patients are well without any signs of increase in tumor size.
我们报告了3例复发性胃癌患者，在接受5-氟尿嘧啶、丝裂霉素C和顺铂联合化疗后对替吉奥（TS-1）治疗有反应。所有3例患者均因进展期胃癌接受了全胃切除术及淋巴结清扫术。术后随访计算机断层扫描（CT）显示，由于癌症复发，出现了肝转移（病例1和3）、腹膜播散（病例2）以及主动脉旁淋巴结肿大（病例1）。在接受2至4个疗程的联合治疗，即5-氟尿嘧啶（500 - 750 mg/体/天，第1 - 5天，持续静脉输注）、丝裂霉素C（6 - 8 mg/体，第6天）和顺铂（60 - 80 mg/体，第7天）后，CT显示转移瘤明显缩小。随后口服替吉奥（80 - 100 mg/体/天）4周。所有3例患者情况良好，无肿瘤大小增加的任何迹象。
