Lojda Z, Jodl J
Cesk Patol. 1975 Aug;11(3):135-9.
Thirty-eight specimens obtained by jejunal biopsy from 22 children suffering from mucoviscidosis were examined by histochemical techniques. In 27% of the patients the findings were within normal limits. In 18% of cases, associated coeliacal sprue was disclosed. The remaining cases displayed slight morphological abnormalities associated with trehalase and/or lactase deficiency, and in 41% there was hypersecretion of viscous mucus filling up dilated crypts and adhering to the surface of villi. The findings as observed in enterobiopsis are not pathognostic of mucoviscidosis. They however, should make one to think of it, particularly if trehalase and/or lactase deficiency is found associated with hypersecretion of viscous mucus and an almost normal morphological appearance. Neither normal findings nor that of coeliacal sprue exclude the diagnosis of mucoviscidosis. It appears that malabsorption in mucoviscidosis is not only pancreatogenic; the intestinal mucosa may be contributory to a various degree as well.
采用组织化学技术检查了从22例患有黏液黏稠病的儿童获取的38份空肠活检标本。27%的患者检查结果在正常范围内。18%的病例发现伴有乳糜泻。其余病例表现出与海藻糖酶和/或乳糖酶缺乏相关的轻微形态学异常，41%的病例存在黏稠黏液分泌过多，充满扩张的隐窝并附着于绒毛表面。在蛲虫病中观察到的这些表现并非黏液黏稠病所特有。然而，它们应促使人们想到这种疾病，特别是当发现海藻糖酶和/或乳糖酶缺乏与黏稠黏液分泌过多及几乎正常的形态外观相关时。正常结果或乳糜泻的结果均不能排除黏液黏稠病的诊断。看来黏液黏稠病中的吸收不良不仅由胰腺引起；肠黏膜在不同程度上也可能起作用。
