注意力缺陷多动障碍与多巴胺β-羟化酶基因
Attention deficit hyperactivity disorder and the gene for dopamine Beta-hydroxylase.
作者信息
Wigg Karen, Zai Gwyneth, Schachar Russell, Tannock Rosemary, Roberts Wendy, Malone Molly, Kennedy James L, Barr Cathy L
机构信息
Department of Psychiatry, Toronto Western Hospital, Ont., Canada.
出版信息
Am J Psychiatry. 2002 Jun;159(6):1046-8. doi: 10.1176/appi.ajp.159.6.1046.
OBJECTIVE
Attention deficit hyperactivity disorder (ADHD) has been shown to be highly heritable, and recent molecular genetics studies have focused on candidate genes in the dopaminergic and noradrenergic systems. One recent study reported an association of an allele of the TaqI polymorphism located in the fifth intron of the gene for dopamine beta-hydroxylase (DBH). The authors' goal was to replicate this finding.
METHOD
The authors investigated the linkage of the alleles and haplotypes of three polymorphisms at the DBH locus in 117 nuclear families with ADHD.
RESULTS
No significant evidence was found for linkage of the TaqI alleles or haplotypes in the 117 families. However, the authors observed some evidence for biased transmission of the same allele of the TaqI polymorphism, as previously reported.
CONCLUSIONS
These findings suggest that the gene for DBH should be investigated further.
目的
注意力缺陷多动障碍（ADHD）已被证明具有高度遗传性，近期的分子遗传学研究聚焦于多巴胺能和去甲肾上腺素能系统中的候选基因。最近一项研究报告称，位于多巴胺β-羟化酶（DBH）基因第五内含子的TaqI多态性的一个等位基因存在关联。作者的目标是重复这一发现。
方法
作者在117个患有ADHD的核心家庭中研究了DBH基因座上三个多态性的等位基因和单倍型的连锁情况。
结果
在这117个家庭中，未发现TaqI等位基因或单倍型连锁的显著证据。然而，正如之前所报道的，作者观察到了TaqI多态性相同等位基因的偏态传递的一些证据。
结论
这些发现表明，应进一步研究DBH基因。
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