Albayrak O, Friedel S, Schimmelmann B G, Hinney A, Hebebrand J
Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg-Essen, Essen, Germany.
J Neural Transm (Vienna). 2008;115(2):305-15. doi: 10.1007/s00702-007-0839-9. Epub 2008 Jan 16.
Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder among children and adolescents with high heritability. Molecular genetic findings support the thesis that dopaminergic, serotonergic, and noradrenergic neurotransmission pathways account for the etiology of this complex disease. Genetic research comprises formal genetic studies, candidate gene studies, linkage analyses, and recently large-scale genome wide association studies, gene-environement interaction studies, and pharmacogenetics. This article comprehensively reviews the latest findings on the genetics of ADHD.
注意缺陷多动障碍（ADHD）是儿童和青少年中一种常见的精神疾病，具有高度遗传性。分子遗传学研究结果支持这样一种观点，即多巴胺能、血清素能和去甲肾上腺素能神经传递途径是这种复杂疾病病因的基础。遗传学研究包括正式遗传学研究、候选基因研究、连锁分析，以及最近的大规模全基因组关联研究、基因-环境相互作用研究和药物遗传学。本文全面综述了ADHD遗传学的最新研究结果。
