Crow Scott J, Thuras Paul, Keel Pamela K, Mitchell James E
Department ofPsychiatry, University of Minnesota Medical School, Minneapolis, 55454-1495, USA.
Am J Psychiatry. 2002 Jun;159(6):1048-50. doi: 10.1176/appi.ajp.159.6.1048.
Menstrual dysfunction occurs frequently in patients with bulimia nervosa. Whether this is associated with diminished fertility is unknown. This study examined menstrual and reproductive function in bulimia nervosa patients retrospectively, with 10-15-year follow-ups.
A total of 173 women with bulimia nervosa were interviewed an average of 11.5 years (SD=1.9) after initial assessment with the Structured Clinical Interview for DSM-IV and a questionnaire about menstruation, pregnancy, and eating disorder symptoms.
At baseline assessment, 38.2% of the subjects reported regular menses, and 4.6% reported amenorrhea. At follow-up, the rate of amenorrhea was 16.8% (2.9% because of pregnancy). At baseline, 34.7% of the subjects had experienced at least one pregnancy. At follow-up, 74.6% had been pregnant at least once, and 1.7% reported an inability to conceive.
These results suggest that while menstrual irregularities are common, bulimia nervosa appears to have little impact on later ability to achieve pregnancy.
神经性贪食症患者经常出现月经功能紊乱。这是否与生育能力下降有关尚不清楚。本研究对神经性贪食症患者的月经和生殖功能进行了回顾性研究，并进行了10至15年的随访。
对173名神经性贪食症女性进行了访谈，这些女性在最初使用《精神疾病诊断与统计手册》第四版的结构化临床访谈以及一份关于月经、怀孕和饮食失调症状的问卷进行评估后，平均随访了11.5年（标准差=1.9）。
在基线评估时，38.2%的受试者报告月经规律，4.6%报告闭经。在随访时，闭经率为16.8%（2.9%是因为怀孕）。在基线时，34.7%的受试者至少经历过一次怀孕。在随访时，74.6%的受试者至少怀孕过一次，1.7%报告无法受孕。
这些结果表明，虽然月经不规律很常见，但神经性贪食症似乎对后期受孕能力影响不大。
