Farebrother D A, Hatfield P, Simmonds H A, Cameron J S, Jones A S, Cadenhead A
Clin Nephrol. 1975 Dec;4(6):241-50.
An acute crystal nephropathy was produced in pigs by feeding a mixture of guanine and allopurinol. The pathogenesis of the lesion produced was studied by serial histology and renal function tests over 12 months. Tubular blockage by the crystals produced erosion of the basement membrane and an accompanying interstitial nephritis. Tubular degeneration around the crystal mass transferred the crystals to the interstitium. Despite rapid subsequent disappearance of these crystals the interstitial nephritis was still evident nine months later. An early return of renal function to near normal was not sustained beyond nine months. It was shown that even brief periods of intratubular crystal deposition caused irreversible changes, resulting eventually in a reduction in kidney size, nephron population and renal function.
通过给猪喂食鸟嘌呤和别嘌呤醇的混合物来诱发急性晶体肾病。通过连续12个月的组织学检查和肾功能测试来研究所产生病变的发病机制。晶体造成的肾小管阻塞导致基底膜侵蚀，并伴有间质性肾炎。晶体团块周围的肾小管变性将晶体转移至间质。尽管这些晶体随后迅速消失，但9个月后间质性肾炎仍然明显。肾功能在9个月后未能维持早期恢复至接近正常的状态。结果表明，即使肾小管内晶体沉积的时间很短也会导致不可逆转的变化，最终导致肾脏大小、肾单位数量和肾功能下降。
