我们爱吃甜食的基因后果。

The genetic consequences of our sweet tooth.

作者信息

Cox Timothy M

机构信息

Department of Medicine, University of Cambridge, Level 5, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.

出版信息

Nat Rev Genet. 2002 Jun;3(6):481-7. doi: 10.1038/nrg815.

DOI:10.1038/nrg815

PMID:12042775

Abstract

First reported in 1956, hereditary fructose intolerance (HFI) illustrates vividly how interactions between genes and nutrients can influence taste preferences; the disease also reflects the ascendancy of sucrose and fructose as energy sources and as the world's principal sweeteners. However, HFI is not the only genetic ill to have emerged from our obsession with sugar: the slave trade, which had such a key part in the development of the sugar industry, also included major genetic consequences in its haunting legacy.

摘要

遗传性果糖不耐受症（HFI）于1956年首次被报道，它生动地说明了基因与营养物质之间的相互作用是如何影响口味偏好的；这种疾病也反映了蔗糖和果糖作为能源以及世界主要甜味剂的主导地位。然而，HFI并不是我们对糖的痴迷所引发的唯一一种遗传疾病：在制糖业发展中起到关键作用的奴隶贸易，在其挥之不去的遗产中也带来了重大的遗传后果。