Magen Daniella, Mandel Hana, Berant Moshe, Ben-Izhak Ofer, Zelikovic Israel
Pediatric Nephrology Unit, Rambam Medical Center, P.O. Box 9602, Haifa 31096, Israel.
Pediatr Nephrol. 2002 May;17(5):370-2. doi: 10.1007/s00467-002-0847-9.
We report a girl with severe congenital neutropenia who has received long-term granulocyte-colony stimulating factor (G-CSF) therapy and has developed macroscopic hematuria, proteinuria, and decreased renal function associated with biopsy-proven membranoproliferative glomerulonephritis (MPGN) type I. Temporary discontinuation of G-CSF therapy as well as the use of glycosylated G-CSF has resulted in improvement in renal manifestations. We postulate that the MPGN was G-CSF-induced. Long-term G-CSF therapy should be used with great caution and close surveillance of kidney function.
我们报告了一名患有严重先天性中性粒细胞减少症的女孩，她接受了长期粒细胞集落刺激因子（G-CSF）治疗，并出现了肉眼血尿、蛋白尿以及与经活检证实的I型膜增生性肾小球肾炎（MPGN）相关的肾功能下降。暂时停用G-CSF治疗以及使用糖基化G-CSF已使肾脏表现得到改善。我们推测MPGN是由G-CSF诱导的。长期使用G-CSF治疗时应极其谨慎并密切监测肾功能。
