Optical resolution of 5-alkyl-delta-valerolactones and synthesis of optically active 5-fluoroalkanols.
作者信息
Riswoko Asep, Aoki Yoshio, Hirose Takuji, Nohira Hiroyuki
机构信息
Department of Applied Chemistry, Faculty of Engineering, Saitama University, Urawa, Japan.
出版信息
Enantiomer. 2002 Jan-Feb;7(1):33-9. doi: 10.1080/10242430210707.
PMID:12043944
Abstract
Optical resolutions of 5-alkyl-delta-valerolactones were carried out by derivatization to the diastereomeric amides, in which (R)-(+)-1-(1-naphthyl)ethylamine or (S)-(-)-1-phenylethylamine were used as resolving agents. Optically active 5-fluoroalkanols, useful intermediates for fluorinated ferroelectric liquid crystals, were derived from the resolved lactones in four steps without racemization.
摘要
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