(R)-苯乙胺对 p-氯扁桃酸的非对映体拆分。
Diastereomeric resolution of p-chloromandelic acid with (R)-phenylethylamine.
机构信息
Department of Chemical Engineering, Ningbo University of Technology, Ningbo 315016, China.
出版信息
Chirality. 2010 Jan;22(1):16-23. doi: 10.1002/chir.20695.
PMID:19205041
Abstract
The optical resolution of p-chloromandelic acid using (R)-alpha-phenylethylamine as resolving agent was presented. The effect of solvents, molar ratio of racemate to the resolving agent, filtration temperature as well as the amount of solvent on resolution was investigated by orthogonal experimentation. The binary melting point phase diagram and crystal structure analysis of diastereomeric salts rationalized the success of the resolution.
摘要
介绍了用（R）-α-苯乙胺作为拆分剂拆分对氯扁桃酸的光学异构体。通过正交实验考察了溶剂、外消旋体与拆分剂的摩尔比、过滤温度以及溶剂用量对拆分的影响。非对映异构体盐的二元熔点相图和晶体结构分析解释了拆分成功的原因。
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