Khachigian Levon M
Centre for Thrombosis and Vascular Research, Department of Pathology, University of New South Wales, Sydney, Australia. L.
Curr Opin Mol Ther. 2002 Apr;4(2):119-21.
DNAzymes are synthetic catalytic deoxyribonucleic acid molecules that can be engineered to bind to their complementary sequence in the target nucleic acid through Watson-Crick base pairing and cleave at predetermined phosphodiester linkages. This article reviews the recent use of DNAzymes as probes of molecular function and their potential applications in clinical medicine.
脱氧核酶是一种人工合成的催化性脱氧核糖核酸分子，可通过沃森-克里克碱基配对设计使其与靶核酸中的互补序列结合，并在预定的磷酸二酯键处进行切割。本文综述了脱氧核酶作为分子功能探针的最新应用及其在临床医学中的潜在应用。
