Rutter Jared, Reick Martin, McKnight Steven L
Department of Biochemistry, University of Texas-Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-9152, USA.
Annu Rev Biochem. 2002;71:307-31. doi: 10.1146/annurev.biochem.71.090501.142857. Epub 2001 Nov 9.
The core apparatus that regulates circadian rhythm has been extensively studied over the past five years. A looming question remains, however, regarding how this apparatus is adjusted to maintain coordination between physiology and the changing environment. The diversity of stimuli and input pathways that gain access to the circadian clock are summarized. Cellular metabolic states could serve to link physiologic perception of the environment to the circadian oscillatory apparatus. A simple model, integrating biochemical, cellular, and physiologic data, is presented to account for the connection of cellular metabolism and circadian rhythm.
在过去五年中，对调节昼夜节律的核心机制进行了广泛研究。然而，一个迫在眉睫的问题仍然存在，即该机制如何进行调整以维持生理机能与不断变化的环境之间的协调。本文总结了能够作用于生物钟的各种刺激和输入途径的多样性。细胞代谢状态可能是将对环境的生理感知与昼夜振荡机制联系起来的纽带。本文提出了一个整合生化、细胞和生理数据的简单模型，以解释细胞代谢与昼夜节律之间的联系。
