Van Gelder Russell N, Herzog Erik D, Schwartz William J, Taghert Paul H
Department of Ophthalmology and Visual Sciences, Washington University, St. Louis, MO 63110, USA.
Science. 2003 Jun 6;300(5625):1534-5. doi: 10.1126/science.1085446.
The basic molecular mechanisms underlying circadian oscillators follow the same general plan across the phylogenetic spectrum: oscillating feedback loops in which clock gene products negatively regulate their own expression. The circadian clocks of animals involve at least two interacting feedback loops. This Viewpoint compares and contrasts the circadian clocks of mammals and of Drosophila, emphasizing how different players are used to create the same basic script. Both the general script and the specific details of the murine and Drosophila circadian pathways are available at Science's Signal Transduction Knowledge Environment Connections Maps.
即振荡反馈回路，其中生物钟基因产物对自身表达进行负调控。动物的昼夜节律钟至少涉及两个相互作用的反馈回路。本观点比较并对比了哺乳动物和果蝇的昼夜节律钟，强调了如何利用不同的元件来构建相同的基本模式。小鼠和果蝇昼夜节律途径的总体模式和具体细节均可在《科学》杂志的信号转导知识环境连接图谱中获取。
