Koo Kyung Ah, Sung Sang Hyun, Kim Young Choong
College of Pharmacy, Seoul National University, Korea.
Chem Pharm Bull (Tokyo). 2002 Jun;50(6):834-6. doi: 10.1248/cpb.50.834.
A new pinusolide derivative, 15-methoxypinusolidic acid (1), and another new isopimarane diterpene, ent-isopimara-15-en-3 alpha,8 alpha-diol (2) with three known diterpenes, lambertianic acid (3), isopimara-8(9),15-dien-18-oic acid (4) and isopimara-7(8),15-dien-3 beta,18-diol (5) were isolated from the 90% MeOH fraction of Biota orientalis (L.) ENDL. (Cupressaceae) leaves. Chemical structures of 1-5 were elucidated by analyses of their spectral data, including the two-dimensional (2D) NMR technique. Compound 1 showed significant protective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells.
从侧柏（柏科）叶的90%甲醇提取物中分离得到一种新的松脂醇衍生物15-甲氧基松脂酸（1）、另一种新的异海松烷二萜对映-异海松-15-烯-3α,8α-二醇（2）以及三种已知的二萜类化合物，扁柏酸（3）、异海松-8(9),15-二烯-18-酸（4）和异海松-7(8),15-二烯-3β,18-二醇（5）。通过对其光谱数据（包括二维（2D）核磁共振技术）的分析阐明了化合物1-5的化学结构。化合物1在大鼠皮层细胞原代培养中对谷氨酸诱导的神经毒性表现出显著的保护活性。
