脉络丛肿瘤中P53的表达：一项免疫组织化学研究
P53 expression in choroid plexus neoplasms: an immunohistochemical study.
作者信息
Jay V, Ho M, Chan F, Malkin D
机构信息
Department of Pathology, The Hospital for Sick Children, University of Toronto, Ontario, Canada.
出版信息
Arch Pathol Lab Med. 1996 Nov;120(11):1061-5.
OBJECTIVE
To evaluate choroid plexus neoplasms for p53 expression.
CASE MATERIAL
We studied 10 choroid plexus tumors (four papillomas and six carcinomas) by immunohistochemistry using the DO7 anti-p53 monoclonal antibody.
RESULTS
Three of four choroid plexus papillomas demonstrated no staining. Scattered nuclear and rare cytoplasmic positivity was present in one papilloma, which showed foci of increased mitotic activity (labeling index 2.5%). Six of six carcinomas were immunoreactive for p53, and three cases had labeling indexes of over 70%. All immunopositive choroid plexus tumors (7/7) exhibited nuclear staining. Punctate cytoplasmic positivity was identified in 5 of 7 cases.
CONCLUSION
Our study suggests that altered p53 expression is detectable by immunohistochemistry in choroid plexus neoplasms and is consistently present in choroid plexus carcinomas.
目的
评估脉络丛肿瘤的p53表达情况。
病例材料
我们使用DO7抗p53单克隆抗体，通过免疫组织化学方法研究了10例脉络丛肿瘤（4例乳头状瘤和6例癌）。
结果
4例脉络丛乳头状瘤中有3例无染色。1例乳头状瘤出现散在核阳性及罕见的胞质阳性，该例显示有丝分裂活性增加灶（标记指数2.5%）。6例癌均对p53免疫反应阳性，3例标记指数超过70%。所有免疫阳性的脉络丛肿瘤（7/7）均显示核染色。7例中有5例发现点状胞质阳性。
结论
我们的研究表明，通过免疫组织化学可检测到脉络丛肿瘤中p53表达改变，且其在脉络丛癌中持续存在。
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