Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.
Brain Tumor Pathol. 2011 Jul;28(3):215-21. doi: 10.1007/s10014-011-0024-6. Epub 2011 Mar 11.
The aim of this study was to summarize the clinicopathological features and the histological diversity of choroid plexus tumors and to examine the expression of immunohistochemical markers that are useful for their differentiation from metastatic cancer. Twenty cases were collected, including 11 choroid plexus papillomas, 5 choroid plexus adenomas, 1 atypical choroid plexus papilloma, and 3 choroid plexus carcinomas. The choroid plexus papillomas showed various parenchymal and stromal changes: focal solid growth, oncocytic alterations, melanin deposition, calcification, ossification, and xanthogranulomatous reactions. The choroid plexus tumors showed the following cytokeratin (CK) 7 and 20 staining patterns: CK7(+)/CK20(+) (11/19 cases), CK7(+)/CK20(-) (7/19 cases), CK7(-)/CK20(-) (1/19 cases), and CK7(-)/CK20(+) (0/19 cases). Positivity for CK5/6 and thyroid transcription factor-1 was found in 3 of 18 and 1 of 19 cases, respectively. All cases were negative for the estrogen receptor (0/18 cases). The choroid plexus tumors showed various CK7/CK20 staining patterns, and the staining of CK7 and CK20 in most CK7(+)/CK20(+) and CK7(+)/CK20(-) cases was focal, in contrast to that observed in carcinomas. Therefore, nondiffuse staining of CK, rather than the CK7/CK20 panel itself, is important for discriminating between a choroid plexus tumor and metastatic cancer.
本研究旨在总结脉络丛肿瘤的临床病理特征和组织学多样性，并研究有助于鉴别其与转移性癌的免疫组织化学标志物的表达情况。收集了 20 例病例，包括 11 例脉络丛乳头状瘤、5 例脉络丛腺瘤、1 例非典型脉络丛乳头状瘤和 3 例脉络丛癌。脉络丛乳头状瘤表现出各种实质和基质变化：局灶性实性生长、嗜酸细胞改变、黑色素沉积、钙化、骨化和黄肉芽肿反应。脉络丛肿瘤的细胞角蛋白（CK）7 和 20 染色模式如下：CK7(+)/CK20(+)（19 例中的 11 例）、CK7(+)/CK20(-)（19 例中的 7 例）、CK7(-)/CK20(-)（19 例中的 1 例）和 CK7(-)/CK20(+)（19 例中无）。3 例中的 CK5/6 和甲状腺转录因子-1 呈阳性，分别为 19 例中的 1 例和 19 例中的 1 例。所有病例均为雌激素受体阴性（18 例中无）。脉络丛肿瘤表现出不同的 CK7/CK20 染色模式，与癌相比，大多数 CK7(+)/CK20(+)和 CK7(+)/CK20(-)病例的 CK7 和 CK20 染色呈局灶性，而非弥漫性。因此，区分脉络丛肿瘤和转移性癌的关键是 CK 的非弥漫性染色，而非 CK7/CK20 免疫组化本身。
