Barry Michael F, Ziff Edward B
Howard Hughes Medical Institute, Department of Biochemistry, New York University Medical Center, New York, New York 10016, USA.
Curr Opin Neurobiol. 2002 Jun;12(3):279-86. doi: 10.1016/s0959-4388(02)00329-x.
Newly discovered features of the trafficking of AMPA receptors to and from the postsynaptic membrane of excitatory synapses are now bringing the mechanisms of synaptic plasticity into focus. Recent advances, including the existence of slots, anchors, transport factors and pathways for activity-dependent control, have elucidated the role of the individual AMPA receptor subunits and their binding partners. The latest views describe how subunit type dictates the assembly of heteromeric receptors, and how these heteromers interact with the receptor trafficking machinery and synaptic anchorage factors. Moreover, phosphorylation may play an important role in receptor transport and synaptic turnover.
AMPA受体在兴奋性突触后膜的内吞与外排过程中出现了一些新发现的特征，这些特征正使突触可塑性机制成为研究焦点。近期的进展，包括缝隙、锚定蛋白、转运因子以及活性依赖调控途径的存在，已经阐明了各个AMPA受体亚基及其结合伴侣的作用。最新观点描述了亚基类型如何决定异聚体受体的组装，以及这些异聚体如何与受体转运机制和突触锚定因子相互作用。此外，磷酸化可能在受体转运和突触更新中发挥重要作用。
