Kuru B, Ozaslan C, Yalman K, Camlýbel M
Department of General Surgery, Ankara Oncology Education and Research Hospital, Ankara, Turkey.
Acta Chir Belg. 2002 Apr;102(2):122-5. doi: 10.1080/00015458.2002.11679278.
It is known that various malignant tissues possess progesterone receptors. It has been reported that the serum progesterone levels increase and show a prognostic significance in gastric carcinoma. We carried out a study to determine the serum progesterone level in gastric cancer, and colorectal cancer.
140 of our patients were male and 56 female. We determined serum progesterone level in patients with gastric cancer, and colorectal cancer. Patients with benign diseases participated in the study as control group.
In male patients with gastric cancer (n = 90) and colorectal cancer (n = 50) the serum progesterone level was not significantly higher than in the control group (n = 80) (mean: 1.08 +/- 0.73, 1.08 +/- 0.32 and 1.01 +/- 0.38 ng/ml, respectively). Among the female patients with gastric cancer (n = 26) and colorectal cancer (n = 30), the serum progesterone level was also not significantly higher than in the control group (n = 30) (mean: 1.19 +/- 0.77, 1.21 +/- 0.72 and 1.12 +/- 0.61 respectively). In males, the sensitivity of progesterone for gastric cancer was 55.5% and 64% for colorectal cancer with a specificity of 37.5%. In females, the sensitivity of progesterone for gastric cancer was 54% and 57% for colorectal patients with a specificity of 40%.
Serum progesterone level does not correlate with the presence or absence of gastric cancer or colorectal cancer, and it is not a useful tumour marker.
已知多种恶性组织含有孕激素受体。据报道，血清孕激素水平在胃癌中升高并具有预后意义。我们开展了一项研究以测定胃癌和结直肠癌患者的血清孕激素水平。
我们的患者中140例为男性，56例为女性。我们测定了胃癌和结直肠癌患者的血清孕激素水平。患有良性疾病的患者作为对照组参与研究。
男性胃癌患者（n = 90）和结直肠癌患者（n = 50）的血清孕激素水平并不显著高于对照组（n = 80）（均值分别为：1.08 ± 0.73、1.08 ± 0.32和1.01 ± 0.38 ng/ml）。女性胃癌患者（n = 26）和结直肠癌患者（n = 30）的血清孕激素水平也不显著高于对照组（n = 30）（均值分别为：1.19 ± 0.77、1.21 ± 0.72和1.12 ± 0.61）。在男性中，孕激素对胃癌的敏感性为55.5%，对结直肠癌的敏感性为64%，特异性为37.5%。在女性中，孕激素对胃癌的敏感性为54%，对结直肠癌患者的敏感性为57%，特异性为40%。
血清孕激素水平与胃癌或结直肠癌的有无无关，它不是一种有用的肿瘤标志物。
