Lorenzi M, Porcelli B, Vannoni D, Leoncini R, Pizzichini M, Di Stefano A, Pagani R, Marinello E
Istituto di Chimica Biologica, Università di Siena, Italy.
Biomed Pharmacother. 1990;44(8):403-7. doi: 10.1016/0753-3322(90)90044-a.
Reverse phase high performance liquid chromatography has been used for the determination of plasma hypoxanthine, xanthine, and uric acid in normal subjects and in patients with gastric and colorectal cancer. Plasma oxypurines are significantly elevated in either type of cancer, while uric acid concentration is only higher in gastric cancer. The variations are related to the stage of the tumors, and the physiopathology of their occurrence is discussed.
反相高效液相色谱法已用于测定正常受试者以及胃癌和结直肠癌患者血浆中的次黄嘌呤、黄嘌呤和尿酸。在这两种癌症中，血浆中氧嘌呤均显著升高，而尿酸浓度仅在胃癌中较高。这些变化与肿瘤分期有关，并对其发生的生理病理学进行了讨论。
