Sucharita S, Bharathi A V, Kurpad Anura V, Vaz Mario
Department of Physiology, St John's Medical College, Bangalore, India.
Physiol Meas. 2002 May;23(2):347-54. doi: 10.1088/0967-3334/23/2/310.
Conventional tests of cardiac parasympathetic nervous system (PNS) activity were compared with the high frequency component of the heart rate power spectrum in a heterogenous group of normal subjects encompassing a wide age range. The data suggest that the linear associations between the various conventional tests of parasympathetic nervous activity even when statistically significant, were relatively modest, with r values ranging from 0.23 to 0.53. Three of the five conventional tests of parasympathetic nervous activity were significantly correlated (r = 0.33 to 0.46) with the absolute high frequency power of RR variability. However, these relationships were poorer and non-significant when the high frequency power spectrum was normalized for total power (r = 0.06 to 0.19, NS). An evaluation of the heart rate responses to cough and a single maximal hand grip indicated that the responses were repeatable but that the extent to which these manoeuvres induced vagally mediated cardioacceleration was significantly lesser than the other conventional tests of PNS activity. Taken together, the data suggest that despite the advent of heart rate variability measures, it is advisable to use multiple tests of parasympathetic nervous activity while evaluating autonomic dysfunction, since, despite the specificity of the tests, there is a variable correlation between them.
在一个涵盖广泛年龄范围的正常受试者异质群体中，将心脏副交感神经系统（PNS）活动的传统测试与心率功率谱的高频成分进行了比较。数据表明，即使在统计学上具有显著意义，副交感神经活动的各种传统测试之间的线性关联也相对较弱，r值范围为0.23至0.53。五项副交感神经活动传统测试中的三项与RR变异性的绝对高频功率显著相关（r = 0.33至0.46）。然而，当高频功率谱针对总功率进行归一化时，这些关系较差且无统计学意义（r = 0.06至0.19，无显著性差异）。对咳嗽和单次最大握力的心率反应评估表明，这些反应是可重复的，但这些动作诱发迷走神经介导的心动加速的程度明显低于PNS活动的其他传统测试。综合来看，数据表明，尽管心率变异性测量方法已经出现，但在评估自主神经功能障碍时，建议使用多种副交感神经活动测试，因为尽管这些测试具有特异性，但它们之间的相关性是可变的。
