Schmid H H O, Berdyshev E V
The Hormel Institute, University of Minnesota, 801-16th Avenue NE, Austin, MN 55912, USA.
Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar;66(2-3):363-76. doi: 10.1054/plef.2001.0348.
Although it is now generally accepted that long-chain N-acylethanolamines and their precursors, N-acylethanolamine phospholipids, exist as trace constituents in virtually all vertebrate cells and tissues, their possible biological functions are just emerging. While anandamide (N-arachidonoylethanolamine) has received much attention due to its ability to bind to and activate cannabinoid receptors, the saturated and monounsaturated N-acylethanolamines, which usually represent the vast majority, are cannabinoid receptor-inactive but appear to interact with endocannabinoids and to have other signaling functions as well. Also, primary fatty acid amides, including the amide of oleic acid, which acts as a sleep-inducing agent, do not interact with cannabinoid receptors but are catabolically related to endocannabinoids. Here we review published information on the occurrence, metabolism, and possible signaling functions of the cannabinoid receptor-inactive N-acylethanolamines and primary fatty acid amides.
尽管现在人们普遍认为长链N-酰基乙醇胺及其前体N-酰基乙醇胺磷脂作为微量成分存在于几乎所有脊椎动物的细胞和组织中，但其可能的生物学功能才刚刚开始显现。虽然花生四烯酸乙醇胺（N-花生四烯酰乙醇胺）因其能够结合并激活大麻素受体而备受关注，但通常占绝大多数的饱和和单不饱和N-酰基乙醇胺不具有大麻素受体活性，但似乎与内源性大麻素相互作用并具有其他信号功能。此外，包括油酸酰胺（一种睡眠诱导剂）在内的初级脂肪酸酰胺不与大麻素受体相互作用，但在代谢上与内源性大麻素相关。在此，我们综述了已发表的关于无大麻素受体活性的N-酰基乙醇胺和初级脂肪酸酰胺的存在、代谢及其可能的信号功能的信息。
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