多发性硬化症：对其发病机制的深入了解揭示了新的治疗靶点。
Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy.
作者信息
Steinman Lawrence, Martin Roland, Bernard Claude, Conlon Paul, Oksenberg Jorge R
机构信息
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, California 94305, USA.
出版信息
Annu Rev Neurosci. 2002;25:491-505. doi: 10.1146/annurev.neuro.25.112701.142913. Epub 2002 Mar 27.
Abstract
Recent technological breakthroughs allowing for large-scale analysis of gene transcripts and large-scale monitoring of the immune response with protein chips are revealing new participants in the pathogenesis of multiple sclerosis. Some of these participants may be useful targets for therapy.
摘要
近期的技术突破使得对基因转录本进行大规模分析以及利用蛋白质芯片对免疫反应进行大规模监测成为可能，这些突破正在揭示多发性硬化症发病机制中的新参与者。其中一些参与者可能是有用的治疗靶点。
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