实验性自身免疫性脑脊髓炎在杂合性golli髓鞘碱性蛋白基因敲除小鼠中的复发率降低。

Experimental autoimmune encephalomyelitis relapses are reduced in heterozygous golli MBP knockout mice.

作者信息

Voskuhl Rhonda R, Pribyl Thomas M, Kampf Kathy, Handley Vance, Liu Hong-biao, Feng JiMing, Campagnoni Celia W, Soldan Samantha S, Messing Albee, Campagnoni Anthony T

机构信息

Reed Neurological Research Center, UCLA Department of Neurology, 710 Westwood Plaza, Los Angeles, CA 90095, USA.

出版信息

J Neuroimmunol. 2003 Jun;139(1-2):44-50. doi: 10.1016/s0165-5728(03)00161-9.

DOI:10.1016/s0165-5728(03)00161-9

PMID:12799019

Abstract

Increased golli MBP (golli) expression has been observed in the peripheral immune system of mice in the relapsing phase of EAE, raising the possibility that golli MBP expression in the periphery may contribute to relapses. Here we describe the generation of golli MBP-deficient mice and a comparison of the clinical course of EAE between heterozygous (golli(+/-)) and wild-type (golli(+/+)) mice. There was no difference between the two groups in incidence of disease, severity of the first episode of disease, or remission after the first episode. However, there was a significant reduction in relapses in golli(+/-) mice vs. controls, suggesting a role for golli proteins in the relapses in EAE.

摘要

在实验性自身免疫性脑脊髓炎（EAE）复发期的小鼠外周免疫系统中，已观察到golli髓鞘碱性蛋白（golli MBP）表达增加，这增加了外周golli MBP表达可能导致复发的可能性。在此，我们描述了golli MBP缺陷小鼠的产生，并比较了杂合子（golli(+/-)）和野生型（golli(+/+)）小鼠之间EAE的临床病程。两组在疾病发病率、首次发病的严重程度或首次发病后的缓解情况方面没有差异。然而，与对照组相比，golli(+/-)小鼠的复发率显著降低，这表明golli蛋白在EAE复发中起作用。