Rodgers R J
Psychopharmacology (Berl). 1979;66(1):93-8. doi: 10.1007/BF00431996.
Three series of experiments were performed to evaluate possible nicotinic cholinergic influences on fighting behaviour in rats. Each series consisted of three tests (naive animals in each test); shock-induced fighting, pain threshold estimation and locomotor activity. In the first series, nicotine (0.25 -- 1.00 mg/kg) was found to produce a dose-dependent inhibition of fighting without altering shock thresholds. However, the highest dose used also significantly reduced rearing in the activity test. In the second series, mecamylamine (a centrally active antinicotinic) produced a facilitation of fighting at low doses (2.5 mg/kg) and an inhibition at higher doses (10 mg/kg). Whilst these effects were unrelated to changes in shock thresholds, the high dose resulted in a reduction in both horizontal activity and rearing. Finally, as a control for possible peripheral effects of nicotinic blockage, a third series examined the behavioural effects of hexamethonium. Low doses of this compound (2.25 -- 4.5 mg/kg) had little effect on fighting whilst higher doses (9 -- 18 mg/kg) attenuated these responses. Interestingly, although hexamethonium had no effect on shock thresholds, the highest dose (18 mg/kg) produced a facilitation of horizontal activity. Results are discussed in relation to the hypothesis of central nicotinic cholinergic inhibition of agonistic behaviour.
进行了三组实验来评估烟碱型胆碱能对大鼠战斗行为可能产生的影响。每组实验包含三项测试（每项测试均使用未经训练的动物）：电击诱发的战斗、痛阈估计和运动活动。在第一组实验中，发现尼古丁（0.25 - 1.00毫克/千克）可产生剂量依赖性的战斗抑制作用，且不会改变电击阈值。然而，所使用的最高剂量也显著降低了活动测试中的竖毛行为。在第二组实验中，美加明（一种中枢活性抗烟碱药）在低剂量（2.5毫克/千克）时促进战斗，而在高剂量（10毫克/千克）时产生抑制作用。虽然这些效应与电击阈值的变化无关，但高剂量导致水平活动和竖毛行为均减少。最后，作为烟碱阻断可能产生的外周效应的对照，第三组实验研究了六甲铵的行为效应。该化合物的低剂量（2.25 - 4.5毫克/千克）对战斗行为影响不大，而高剂量（9 - 18毫克/千克）则减弱了这些反应。有趣的是，尽管六甲铵对电击阈值没有影响，但最高剂量（18毫克/千克）却促进了水平活动。本文根据中枢烟碱型胆碱能抑制攻击行为的假说对结果进行了讨论。
