Fox I H, Keystone E C, Gladman D D, Moore M, Cane D
Immunol Commun. 1975;4(5):419-27. doi: 10.3109/08820137509057330.
The effect of adenosine on the proliferative response of human peripheral circulating lymphocytes to stimulation by concanavalin A, phytohemagglutinin and pokeweed mitogen was evaluated. Increasing concentrations of adenosine substantially inhibited mitogen mediated lymphocyte blastogenesis. Erythro-9(2-hydroxyl-3-nonyl) adenine. HCl enhanced the inhibitory effect of adenosine. Inosine, the deamination product of adenosine, had an inhibitory effect which was less than that of adenosine. Inhibition by adenosine may be relevant to the normal regulation of immune function and may account in part for the pathophysiological relationship between severe combined immunodeficiency disease and adenosine deaminase deficiency.
评估了腺苷对人外周循环淋巴细胞在刀豆球蛋白A、植物血凝素和商陆有丝分裂原刺激下增殖反应的影响。腺苷浓度增加会显著抑制有丝分裂原介导的淋巴细胞母细胞生成。盐酸erythro-9(2-羟基-3-壬基)腺嘌呤增强了腺苷的抑制作用。肌苷是腺苷的脱氨产物，其抑制作用小于腺苷。腺苷的抑制作用可能与免疫功能的正常调节有关，并且可能部分解释严重联合免疫缺陷病与腺苷脱氨酶缺乏之间的病理生理关系。
