Johnson K P, Feldman E G, Byington D P
Infect Immun. 1975 Dec;12(6):1464-9. doi: 10.1128/iai.12.6.1464-1469.1975.
Syrian golden hamsters were thymectomized in the first 48 h of life, raised, and then inoculated intracerebrally with the HBS strain of hamster-adapted subacute sclerosing panencephalitis virus when over 12 weeks old. Two groups soon become apparent; one group showed progressive neurological susmptoms and the other group remained healthy. The sick hamsters became moribund between days 8 and 17 postinoculation, and they had large amounts of complete virus in their brains, no antibodies to measles virus in their sera, and a demonstrated lack of thymus tissue. Pathological changes in the central nervous system included marked focal necrosis, numerous giant and inclusion-bearing cells, and slight inflammation. The healthy animals, killed at day 22 or 35 postinoculation, contained no central nervous system virus, moderate amounts of measles antibody in their sera, minimal or absent central nervous system pathology, and histologically identifiable remnants of thymus tissue. These studeis indicate that, in the hamster, the immune system is essential in recovering from central nervous system measles infection and that the antibody response to measles probably requires helper T lymphocytes to develop. Im the absence of antibody to measles, the virus did not undergo modification to a cell-associated state, as noted in previous hamster studies and in human subacute aclerosing panencephalitis. This model system may be useful for passive transfer studies to further clarify the effect of the n vivo immune response to acute and persistent central nervous system measles virus infections9
叙利亚金黄地鼠在出生后的头48小时内进行胸腺切除，饲养长大，然后在12周龄以上时脑内接种仓鼠适应株亚急性硬化性全脑炎病毒（HBS株）。很快出现了两组情况；一组出现进行性神经症状，另一组保持健康。患病地鼠在接种后第8至17天之间濒死，它们的大脑中有大量完整病毒，血清中没有麻疹病毒抗体，并且证实没有胸腺组织。中枢神经系统的病理变化包括明显的局灶性坏死、大量的巨细胞和含包涵体的细胞以及轻微炎症。在接种后第22天或35天处死的健康动物，其中枢神经系统中没有病毒，血清中有适量的麻疹抗体，中枢神经系统病理轻微或无病理变化，并且组织学上可识别出胸腺组织的残余。这些研究表明，在地鼠中，免疫系统对于从中枢神经系统麻疹感染中恢复至关重要，并且对麻疹的抗体反应可能需要辅助性T淋巴细胞才能产生。正如之前在地鼠研究和人类亚急性硬化性全脑炎中所指出的，在没有麻疹抗体的情况下，病毒不会转变为细胞相关状态。这个模型系统可能有助于进行被动转移研究，以进一步阐明体内免疫反应对急性和持续性中枢神经系统麻疹病毒感染的影响。
